Methicillin Resistant Staph Aureus (MRSA) infections of the skin may present as boils or abscesses that do not respond to normal antibiotics. It should be suspected when an individual presents with a boil or a non-healing sore, particularly when the usual measures are not effective. Culture is usually mandatory and treatment with more aggressive antibiotics is required. Occasionally opening and draining a boil may be the only treatment necessary but many times more aggressive therapy is required.